NEW
🩸 Berberine
Cost per serving
$0.29
120 servings · ~120-day supply
amino · 9 active deals
The best-value NAC right now is about $0.08 per dose — across 9 tracked products the median is $0.320/dose, so shopping on cost-per-dose can cut your cost several-fold. Every NAC deal here is ranked by cost per dose— what you actually pay per serving, not the sticker price — because forms and absorption differ, so the cheapest bottle isn’t always the cheapest dose.
Right now the best value across our full NAC catalog is at $0.08 per serving.
N-acetylcysteine (NAC) is a modified amino acid. It is the mainstay of therapy for acetaminophen toxicity and is almost 100% effective when given within 8 hours post-ingestion, and it is also approved for conditions with abnormal, viscid, or inspissated mucous secretions such as pneumonia, bronchitis, cystic fibrosis, and tracheostomy care. The article notes it is studied/used off-label for acute hepatic failure, prevention of contrast-induced nephropathy, and topical treatment of keratoconjunctivitis sicca, plus experimental applications in psychiatric conditions (schizophrenia, bipolar disorder), gastrointestinal disorders, critical care, and conditions such as sickle cell disease. — per StatPearls (NCBI Bookshelf); not medical advice.
Available as a 20% concentration in 30 mL vials for IV use (requiring dilution because of high osmolarity, 2600 mOsmol/L) and as 10% and 20% vials for inhalation or oral use; acetaminophen overdose is treated via a 21-hour IV protocol or a 72-hour oral protocol. Time to peak is about 1 to 2 hours when nebulized and around 2 hours for the oral effervescent form, with a terminal half-life of about 5.6 hours after a single IV dose. — per StatPearls (NCBI Bookshelf).
Oral NAC may cause nausea, vomiting, diarrhea, flatus, and gastroesophageal reflux, with vomiting in up to 33% of cases, while IV NAC can cause rate-related anaphylactoid reactions in up to 18% of patients (mild 6%, moderate 10%, severe including bronchospasm and hypotension rare at 1%). IV use may also cause a spurious increase in INR that normalizes when the infusion stops, a false-positive urine ketone result, and acute flushing/erythema; signs of toxicity include hemolysis, thrombocytopenia, metabolic acidosis, acute renal failure, and elevated bilirubin, and massive overdose has caused cerebral edema, seizures, and permanent brain injury. — per StatPearls (NCBI Bookshelf).
Coadministration with nitroglycerin may result in hypotension and nitroglycerin-induced headache. Bronchospasm more commonly occurs in patients with pre-existing reactive airway diseases like asthma, so NAC should be used cautiously in those with a history of bronchospasm or asthma (with a bronchodilator given 10 to 15 minutes before nebulization); in patients prone to fluid overload (eg, cardiomyopathy or congestive heart failure) the diluent fluid quantity must be appropriately titrated, and patients require monitoring for anaphylactoid reactions during IV administration. — per StatPearls (NCBI Bookshelf).
Every NAC deal above is ranked by real cost per dose with no paid placement — see our and .
Independent third-party testing is a voluntary check of a product's identity, potency and contaminants by an outside lab. It's a quality signal, not a value or efficacy claim. Confirm any brand's current status on the official registries:
Testing status is self-reported by the brand or drawn from public certification and may change — always verify on the official registry before purchase.
NAC is not an essential nutrient and has no ; the doses described are clinical protocols rather than general supplement amounts. For acetaminophen toxicity, an oral regimen uses a 140 mg/kg loading dose followed by 70 mg/kg every 4 hours for 17 more doses, and there is a weight-based IV protocol; as an inhaled mucolytic, 3-5 mL of a 20% solution (or 6-10 mL of a 10% solution) is described 3 or 4 times a day. — per StatPearls (NCBI Bookshelf); general information, not medical advice.
Per this page, NAC is FDA-approved as the mainstay of therapy for acetaminophen toxicity (reported as almost 100% effective if given within 8 hours post-ingestion) and as a mucolytic for conditions with abnormal or thick mucus such as pneumonia, bronchitis, and cystic fibrosis. It is also studied off-label for uses like acute hepatic failure, prevention of contrast-induced nephropathy, and psychiatric conditions, with some uses described as still experimental. — per StatPearls (NCBI Bookshelf); general information, not medical advice.
Oral NAC may cause nausea, vomiting, diarrhea, flatus, and gastroesophageal reflux, with vomiting reported in up to 33% of cases. Intravenous NAC can cause rate-related anaphylactoid reactions in up to 18% of patients (mostly mild or moderate, with severe reactions like bronchospasm and hypotension rare at about 1%); if such a reaction occurs the page states NAC should be stopped immediately and the patient treated with an antihistamine and IV fluids. — per StatPearls (NCBI Bookshelf); general information, not medical advice.
We link primary sources and paraphrase their findings — never copy their text, tables, or images. Cost-per-dose figures are our own first-party catalog data.
Cost per serving
$0.29
120 servings · ~120-day supply
Cost per serving
$0.40
60 servings · ~60-day supply
Cost per serving
$0.60
30 servings · ~30-day supply
Cost per serving
$0.42
Avg240 servings · ~240-day supply
Cost per serving
$0.08
Cheap·−88%300 servings · ~300-day supply
Cost per serving
$0.32
Avg·−50%100 servings · ~100-day supply
Cost per serving
$0.17
120 servings · ~120-day supply
Cost per serving
$0.43
Pricey90 servings · ~90-day supply
Cost per serving
$0.09
Cheap·−87%250 servings · ~250-day supply
Amazon.com · 🩸 Berberine
CPS
Price
$34.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$23.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$17.95
Pure Encapsulations · Amazon.com · 🫁 NAC
CPS
Price
$101.00
Amazon.com · 🫁 NAC
CPS
Price
$24.80
Vital Nutrients · Amazon.com · 🫁 NAC
CPS
Price
$31.99
Amazon.com · ✨ Glutathione
CPS
Price
$19.95
Pure Encapsulations · Amazon.com · 🫁 NAC
CPS
Price
$38.50
NOW Foods · Amazon.com · 🫁 NAC
CPS
Price
$21.85
The page notes that nitroglycerin interacts moderately with NAC, and that coadministration may result in hypotension and nitroglycerin-induced headache. It also notes that NAC can result in a lower-than-desired blood concentration of carbamazepine, and can cause a spurious increase in INR and a false-positive result for urine ketones. — per StatPearls (NCBI Bookshelf); general information, not medical advice.
The page advises caution in patients prone to fluid overload (such as those with cardiomyopathy or congestive heart failure), those requiring fluid restriction, and those under 40 kg, with dose volume adjustments noted for older adults. It also states that patients with a history of asthma or bronchospasm require monitoring, and that hepatic function tests (ALT, AST, bilirubin, prothrombin time) and watching for anaphylactoid reactions are necessary. — per StatPearls (NCBI Bookshelf); general information, not medical advice.
NAC 600mg Non-GMO, Gluten Free,Organic NAC Supplement N-Acetyl Cysteine Capsules… at $0.08 per serving — the lowest cost-per-dose nac in our catalog. See the full ranking on the Best NAC page.
We're tracking 9 active NAC deals across Amazon US and partner retailers, ranked by community votes and cost-per-dose — not paid placement.
Across 9 tracked NAC deals the median cost-per-dose is $0.320; the cheapest quartile comes in under $0.166 per serving. Anything below the median is a solid deal for the same molecule.
Deals are submitted by the community and ranked by net votes (hot minus cold) plus cost-per-dose normalised across container sizes. We take no affiliate kickbacks for ordering; sponsored slots, when present, are clearly badged.
Oral NAC may cause nausea, vomiting, diarrhea, flatus, and gastroesophageal reflux, with vomiting in up to 33% of cases, while IV NAC can cause rate-related anaphylactoid reactions in up to 18% of patients (mild 6%, moderate 10%, severe including bronchospasm and hypotension rare at 1%). IV use may also cause a spurious increase in INR that normalizes when the infusion stops, a false-positive urine ketone result, and acute flushing/erythema; signs of toxicity include hemolysis, thrombocytopenia, metabolic acidosis, acute renal failure, and elevated bilirubin, and massive overdose has caused cerebral edema, seizures, and permanent brain injury. — per StatPearls (NCBI Bookshelf).
Dosage, upper-limit, deficiency, food-source and interaction facts are sourced from the NIH Office of Dietary Supplements NAC fact sheet. General information, not medical advice.
