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Melatonin
other · 68 active deals
How much does Melatonin cost?
The best-value Melatonin right now is about $0.02 per dose — across the 67 we can price per dose the median is $0.103/dose, so shopping on cost-per-dose can cut your cost several-fold. Every Melatonin deal here is ranked by cost per dose — what you actually pay per serving, not the sticker price — because forms and absorption differ, so the cheapest bottle isn’t always the cheapest dose.
Prices checked · live from the Amazon US catalog.
Right now the best value across our full Melatonin catalog is at $0.02 per serving.
Median $0.103/servingCheapest quartile under $0.070across 67 tracked Melatonin deals
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What Melatonin does
Melatonin is a hormone the brain produces in response to darkness, and supplemental forms have been studied for several sleep-related and other conditions. Research suggests melatonin supplements may help with jet lag, and studies in children with sleep disorders found it better than placebo for time to fall asleep and total sleep; there is also strong evidence it is better than placebo at reducing anxiety before surgery. For chronic insomnia there is not enough strong evidence on its effectiveness or safety, shift-work studies were generally small or inconclusive, cancer studies have been small with mixed results, and for delayed sleep-wake phase disorder it is uncertain whether the benefits outweigh the possible harms — per the NIH National Center for Complementary and Integrative Health; not medical advice.
Forms & absorption
Melatonin supplements can be made from animals or microorganisms but are most often made synthetically; product quality is a concern, as a 2017 study of 31 supplements found the melatonin amount often did not match the label and 26 percent contained serotonin, and a 2023 study found 22 of 25 over-the-counter melatonin gummy products were inaccurately labeled — per the NIH National Center for Complementary and Integrative Health.
What the evidence shows for Melatonin
Melatonin supplements may help with certain conditions — jet lag, delayed sleep-wake phase disorder, some sleep disorders in children, and anxiety before and after surgery — though the jet-lag and DSWPD evidence comes from small-to-medium reviews and for DSWPD it's uncertain whether the benefits outweigh possible harms — per the U.S. National Center for Complementary and Integrative Health (NCCIH).
Melatonin — safety & side effects
Short-term use of melatonin supplements appears to be safe for most people, but information on long-term safety is lacking; reported side effects in adults include headache, dizziness, nausea, and sleepiness, and in children drowsiness, increased bedwetting or evening urination, headache, dizziness, and agitation. There is a lack of research on safety during pregnancy or breastfeeding, and experts recommend against melatonin use by people with dementia — per the NIH National Center for Complementary and Integrative Health.
Melatonin — interactions & cautions
People taking medicine should consult their health care providers before using melatonin; in particular, people with epilepsy and those taking blood-thinner medications need to be under medical supervision when taking melatonin supplements. Cancer patients should talk with their health care providers to make sure all aspects of their care work together — per the NIH National Center for Complementary and Integrative Health.
When and how to take Melatonin
Take melatonin about one to two hours before your target bedtime, and start with a low dose (0.5–3 mg) — more is not better and larger doses can leave you groggy. It works best short-term and for shifting a schedule (jet lag, late nights), not as a nightly sedative.
Can you take Melatonin with other supplements?
Melatonin can add to the effect of sedatives and blood-pressure or blood-thinning medication — check with your clinician if you take any. Avoid alcohol with it.
Melatonin side effects
Morning grogginess, vivid dreams, and headache are the usual effects, mostly at higher doses.
General guidance on timing and absorption, not medical advice. Check with a clinician about your medications and conditions.
Nature's Truth Melatonin 10mg Gummies | 70 Count | Berry…
Nature's TruthAmazon.com
$0.09/serving
$6.490°
Vitamatic Sugar Free Melatonin 60 mg Per Serving - 60 Gummies
VitamaticAmazon.com
$0.33/serving
$19.990°
Piping Rock Melatonin 3mg | 180 Fast Dissolve Tablets | Berry…
Piping RockAmazon.com
$0.02/serving
$4.490°
Vitafusion Melatonin Gummies Sugar Free | 3mg Per 2 Gummies…
VitafusionAmazon.com
$0.21/serving
$14.630°
Life Extension Melatonin, Sleep Support, 3 mg, 60 Capsules
Life ExtensionAmazon.com
$0.13/serving
$7.500°
Piping Rock Melatonin Gummies 10mg | 70 Count | Berry Flavor…
Piping RockAmazon.com
$0.07/serving
$4.990°
Nature's Bounty Melatonin, 3mg, 120 Quick Dissolve Tablets
Nature's BountyAmazon.com
$0.06/serving
$7.440°
Source Naturals Time Released Melatonin* - 3 mg, 120 Tablets
Source NaturalsAmazon.com
$0.12/serving
$14.630°
Every Melatonin deal above is ranked by real cost per dose with no paid placement — see our and .
Independent testing
1 of 14 tracked Melatonin brands here are flagged as carrying independent third-party testing — a voluntary check of a product's identity, potency and contaminants by an outside lab. It's a quality signal, not a value or efficacy claim. Confirm any brand's current status on the official registries:
Testing status is self-reported by the brand or drawn from public certification and may change — always verify on the official registry before purchase.
Melatonin — dosage, safety & deals FAQ
- What is melatonin used for?
Melatonin is a hormone the brain produces, and supplements have been studied for sleep-related issues; research suggests it may help with jet lag and appears to help with delayed sleep-wake phase disorder, though it's uncertain whether the benefits outweigh possible harms, and there isn't enough strong evidence to recommend it for chronic insomnia. — per the NIH National Center for Complementary and Integrative Health; general information, not medical advice.
- Is melatonin safe? What are the side effects?
Short-term use of melatonin supplements appears to be safe for most people, but information on its long-term safety is lacking and possible long-term side effects are unclear; reported mild side effects in adults include headache, dizziness, nausea, and sleepiness. — per the NIH National Center for Complementary and Integrative Health; general information, not medical advice.
- Does melatonin interact with any medications?
As with all dietary supplements, people taking medicine should consult their health care providers before using melatonin; in particular, people with epilepsy and those taking blood thinner medications need to be under medical supervision when taking it. — per the NIH National Center for Complementary and Integrative Health; general information, not medical advice.
- Who should avoid melatonin or use caution?
There's been a lack of research on melatonin's safety during pregnancy or breastfeeding; it may stay active longer in older people and cause daytime drowsiness, and guidelines recommend against its use by people with dementia; parents considering giving it to children should first speak with a health care provider. — per the NIH National Center for Complementary and Integrative Health; general information, not medical advice.
Melatonin guides
Related supplements
References & sources
- Melatonin: What You Need To Know — NIH National Center for Complementary and Integrative Health
- USP Verified product participants — U.S. Pharmacopeia
- NSF certified products — NSF
We link primary sources and paraphrase their findings — never copy their text, tables, or images. Cost-per-dose figures are our own first-party catalog data.