Best SAM-e

The best sam-e we track, ranked by real cost-per-dose — not paid placements. Across 21 tracked options the typical dose runs $0.40 per serving.

Prices checked Jun 23, 2026

Best valueSAM-e 400mg Capsules - Easy Absorption SAM e Supplement 400mg…

$0.18 per serving — the cheapest sam-e dose we track.

$15.96

$0.18/serving

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Full ranking by cost per dose

Cost-per-serving normalizes price across bottle sizes — a 60-count and a 365-count compare fairly. Top 20 of 21 shown.

#	Product	Form · dose	Servings	Price	$ / serving
1	SAM-e 400mg Capsules - Easy Absorption SAM e Supplement…	capsule · 400mg	90	$15.96	$0.18
2	500mg SAM-e Supplement - High Strength 500mg…	capsule · 500mg	180	$31.96	$0.18
3	Infusions Maximum Strength Pure SAM-e 1200mg 90…	capsule · 1200mg	90	$18.88	$0.21
4	Quorinthiumax SAM e Supplement 500mg - Extra Strength…	capsule · 500mg	120	$27.74	$0.23
5	Nutricost SAM-e (S-Adenosyl-L-Methionine) 400mg Per…	capsule · 400mg	120	$28.76	$0.24
6	1100mg SAM-e (S-Adenosyl-L-Methionine)	tablet · 1100mg	120	$29.59	$0.25
7	1200 MG SAM e Supplement for Brain	tablet · 1200mg	120	$31.34	$0.26
8	1500mg SAM-e Supplement - High Strength…	capsule · 1500mg	90	$23.96	$0.27
9	1200 MG SAM e Supplement for Brain	tablet · 1200mg	60	$16.31	$0.27
10	NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine)200…	capsule · 200mg	60	$23.10	$0.39
11	SAM-e 1000mg Per Tablet	tablet · 1000mg	60	$23.99	$0.40
12	Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2…	tablet · 400mg	120	$49.28	$0.41
13	Nature's Trove SAM-e 400mg 90 Enteric Coated Caplets.…	tablet · 400mg	90	$40.11	$0.45
14	Nature's Trove SAM-e 400mg 30 Enteric Coated Caplets.…	tablet · 400mg	30	$17.71	$0.59
15	Nature Made SAM-e 200mg Complete	tablet · 200mg	60	$45.85	$0.76
16	Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood…	tablet · 400mg	60	$52.50	$0.88
17	Designs for Health Same Capsules with B6	capsule · 200mg	90	$103.99	$1.16
18	SAM-e Complete 400 mg Tablets	tablet · 400mg	36	$55.88	$1.55
19	Designs for Health Same Capsules with B6	capsule · 200mg	30	$48.39	$1.61
20	BulkSupplements.com Same Powder - S-Adenosyl-L-Methionin…	powder · 400mg	1	$20.97	$20.97

Frequently asked

What is the best-value SAM-e supplement?+

SAM-e 400mg Capsules - Easy Absorption SAM e Supplement 400mg… — $0.18 per serving ($15.96 for 90 servings), the lowest cost-per-dose sam-e in our Amazon US catalog as of June 2026.

What is the typical cost per dose for SAM-e?+

About $0.40 per serving across 21 tracked sam-e products, ranging from $0.25 for the best deals to $0.88 for premium options.