NEW
🍎 Apple cider vinegar
Cost per serving
$0.38
60 servings · ~60-day supply
vitamin · 103 active deals
The best-value Vitamin B6 right now is about $0.03 per dose — across 77 tracked products the median is $0.100/dose, so shopping on cost-per-dose can cut your cost several-fold. Every Vitamin B6 deal here is ranked by cost per dose— what you actually pay per serving, not the sticker price — because forms and absorption differ, so the cheapest bottle isn’t always the cheapest dose.
Right now the best value across our full Vitamin B6 catalog is at $0.03 per serving.
Recommended daily intake
Long-term high doses can cause nerve symptoms; respect the upper limit. General FDA/NIH adult guidance — not medical advice.
Vitamin B6 is a water-soluble vitamin whose coenzyme forms are involved in more than 100 enzyme reactions, mostly concerned with protein and amino acid metabolism, as well as the metabolism of carbohydrates and lipids. It plays a role in cognitive development through the biosynthesis of neurotransmitters, in maintaining normal blood levels of homocysteine, and it is involved in gluconeogenesis and glycogenolysis, immune function, and hemoglobin formation. It has been studied as a supplement for cardiovascular disease (by lowering homocysteine), cancer, cognitive decline in older adults, premenstrual syndrome, and nausea and vomiting in pregnancy; however, the NIH notes the research to date provides little evidence that supplemental B6 reduces cardiovascular or cancer risk, finds insufficient evidence for an effect on cognitive function, and reports that while B6 shows promise for PMS the studies are of poor quality and findings for morning sickness are mixed, so more research is needed before drawing firm conclusions. — per the NIH Office of Dietary Supplements; not medical advice.
The most common vitamin B6 form in supplements is pyridoxine (as pyridoxine hydrochloride [HCl]), though some supplements contain pyridoxal 5'-phosphate (PLP). It is sold in multivitamins, B-complex supplements, and as a stand-alone product, available as oral capsules or tablets (including sublingual and chewable tablets) and liquids. According to the NIH, absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various supplement forms.
Vitamin B6 is found in a wide variety of foods, and its richest sources include fish, beef liver and other organ meats, potatoes and other starchy vegetables, and fruit (other than citrus). In the United States, adults obtain most of their dietary vitamin B6 from fortified cereals, beef, poultry, starchy vegetables, and some noncitrus fruits; about 75% of vitamin B6 from a mixed diet is bioavailable — per the NIH Office of Dietary Supplements.
Frank deficiencies are relatively rare in the U.S., but groups most likely to have inadequate vitamin B6 include people with impaired renal function (such as end-stage renal disease or those on dialysis), people with autoimmune disorders like rheumatoid arthritis and malabsorptive conditions (celiac disease, Crohn's disease, ulcerative colitis), and people with alcohol dependence. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function; in infants it can cause irritability, abnormally acute hearing, and convulsive seizures — per the NIH Office of Dietary Supplements.
Every Vitamin B6 deal above is ranked by real cost per dose with no paid placement — see our and .
1 of 8 tracked Vitamin B6 brands here are flagged as carrying independent third-party testing — a voluntary check of a product's identity, potency and contaminants by an outside lab. It's a quality signal, not a value or efficacy claim. Confirm any brand's current status on the official registries:
Testing status is self-reported by the brand or drawn from public certification and may change — always verify on the official registry before purchase.
The rises with age. Adults 19-50 need 1.3 mg; men 51+ need 1.7 mg and women 51+ need 1.5 mg. Children range from 0.5 mg (1-3 yrs) to 1.0 mg (9-13 yrs). Pregnancy is 1.9 mg and lactation 2.0 mg. Infants have Adequate Intakes of 0.1-0.3 mg. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Yes. The for adults 19+ is 100 mg/day. Chronic intake of 1-6 g oral pyridoxine daily for 12-40 months can cause severe, progressive sensory neuropathy with ataxia. Other effects include painful skin lesions, photosensitivity, and gastrointestinal symptoms like nausea and heartburn. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling lips, cracked mouth corners), glossitis (swollen tongue), depression and confusion, and weakened immune function. In infants it causes irritability, abnormally acute hearing, and convulsive seizures. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Groups most likely to have inadequate vitamin B6 include people with impaired renal function (end-stage renal disease, chronic renal insufficiency, dialysis, or kidney transplant), those with autoimmune disorders such as rheumatoid arthritis, celiac disease, Crohn's disease, and ulcerative colitis, and people with alcohol dependence. — per the NIH Office of Dietary Supplements; general information, not medical advice.
We link primary sources and paraphrase their findings — never copy their text, tables, or images. Cost-per-dose figures are our own first-party catalog data.
High intakes of vitamin B6 from food sources have not been reported to cause adverse effects, but chronic intake of 1–6 g of oral pyridoxine per day for 12–40 months can cause severe, progressive sensory neuropathy with ataxia; other effects include painful, disfiguring skin lesions, photosensitivity, and gastrointestinal symptoms such as nausea and heartburn. The Food and Nutrition Board set a Tolerable Upper Intake Level (UL) of 100 mg/day for adults, with lower ULs for children and adolescents — per the NIH Office of Dietary Supplements.
Cost per serving
$0.38
60 servings · ~60-day supply
Cost per serving
$0.11
90 servings · ~90-day supply
Cost per serving
$0.15
60 servings · ~60-day supply
Cost per serving
$0.17
60 servings · ~60-day supply
Cost per serving
$0.18
120 servings · ~120-day supply
Cost per serving
$0.45
Cost per serving
$0.36
90 servings · ~90-day supply
Cost per serving
$0.14
Cost per serving
$0.20
120 servings · ~120-day supply
Cost per serving
$0.41
60 servings · ~60-day supply
Cost per serving
$0.06
180 servings · ~180-day supply
Cost per serving
$0.17
120 servings · ~120-day supply
Cost per serving
$0.17
60 servings · ~60-day supply
Cost per serving
$0.31
50 servings · ~50-day supply
Cost per serving
$0.25
120 servings · ~120-day supply
Cost per serving
$0.28
100 servings · ~100-day supply
Cost per serving
$0.06
180 servings · ~180-day supply
Cost per serving
$0.50
60 servings · ~60-day supply
Cost per serving
$0.19
70 servings · ~70-day supply
Cost per serving
$0.33
Pricey60 servings · ~60-day supply
Cost per serving
$0.17
Avg·−33%Cost per serving
$0.32
120 servings · ~120-day supply
Cost per serving
$0.10
Avg·−50%100 servings · ~100-day supply
Cost per serving
$0.32
60 servings · ~60-day supply
Cost per serving
$0.17
Avg·−33%120 servings · ~120-day supply
Cost per serving
$0.04
Cheap·−83%500 servings · ~500-day supply
Cost per serving
$0.11
Avg·−48%120 servings · ~120-day supply
Cost per serving
$0.07
Avg·−67%250 servings · ~250-day supply
Cost per serving
$1.07
30 servings · ~30-day supply
Cost per serving
$0.06
Avg·−74%100 servings · ~100-day supply
Cost per serving
$0.03
Cheap·−85%250 servings · ~250-day supply
Cost per serving
$0.04
Cheap·−83%250 servings · ~250-day supply
Cost per serving
$0.04
Cheap·−85%250 servings · ~250-day supply
Cost per serving
$0.06
Cheap·−75%120 servings · ~120-day supply
Cost per serving
$0.06
Cheap·−75%250 servings · ~250-day supply
Cost per serving
$0.25
Pricey60 servings · ~60-day supply
Cost per serving
$0.04
Cheap·−84%Cost per serving
$0.21
Pricey90 servings · ~90-day supply
Cost per serving
$0.12
Avg·−44%90 servings · ~90-day supply
Cost per serving
$0.07
Avg·−67%250 servings · ~250-day supply
Cost per serving
$0.09
Avg·−57%100 servings · ~100-day supply
Cost per serving
$0.09
Avg·−54%50 servings · ~50-day supply
Cost per serving
$0.04
Cheap·−83%250 servings · ~250-day supply
Cost per serving
$0.03
Cheap·−85%250 servings · ~250-day supply
Cost per serving
$0.04
Cheap·−83%250 servings · ~250-day supply
Cost per serving
$0.22
120 servings · ~120-day supply
Cost per serving
$0.21
120 servings · ~120-day supply
Cost per serving
$0.34
70 servings · ~70-day supply
Amazon.com · 🍎 Apple cider vinegar
CPS
Price
$23.00
Amazon.com · 🍎 Apple cider vinegar
CPS
Price
$9.99
Amazon.com · 🍎 Apple cider vinegar
CPS
Price
$8.82
Amazon.com · 🍎 Apple cider vinegar
CPS
Price
$9.99
Amazon.com · 🍎 Apple cider vinegar
CPS
Price
$21.99
Amazon.com · 🌙 Magnesium
CPS
Price
$20.09
Amazon.com · 🌙 Magnesium
CPS
Price
$32.20
Amazon.com · 🌙 Magnesium
CPS
Price
$32.97
Amazon.com · 🌙 Magnesium
CPS
Price
$23.99
Amazon.com · 🌙 Magnesium
CPS
Price
$24.79
Amazon.com · 🌙 Magnesium
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$19.95
Amazon.com · 🅱️ B-Complex
CPS
Price
$9.99
Bluebonnet · Amazon.com · 🅱️ B-Complex
CPS
Price
$15.60
Amazon.com · 🅱️ B-Complex
CPS
Price
$29.59
Bluebonnet · Amazon.com · 🅱️ B-Complex
CPS
Price
$27.60
Carlyle · Amazon.com · 🅱️ B-Complex
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$29.95
Amazon.com · 🅱️ B-Complex
CPS
Price
$13.49
Amazon.com · 🧠 Vitamin B6
CPS
Price
$19.99
Amazon.com · 🧠 Vitamin B6
CPS
Price
$19.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$37.99
Amazon.com · 🧠 Vitamin B6
CPS
Price
$9.99
Amazon.com · 🌙 Magnesium
CPS
Price
$18.99
Amazon.com · 🧠 Vitamin B6
CPS
Price
$19.99
Amazing Formulas · Amazon.com · 🧠 Vitamin B6
CPS
Price
$19.99
Best Naturals · Amazon.com · 🧠 Vitamin B6
CPS
Price
$12.99
Best Naturals · Amazon.com · 🧠 Vitamin B6
CPS
Price
$17.99
Amazon.com · 🤰 Prenatal Vitamin
CPS
Price
$31.99
Amazon.com · 🧠 Vitamin B6
CPS
Price
$5.99
Carlyle · Amazon.com · 🧠 Vitamin B6
CPS
Price
$8.72
Amazing Formulas · Amazon.com · 🧠 Vitamin B6
CPS
Price
$9.99
Vitamatic · Amazon.com · 🧠 Vitamin B6
CPS
Price
$8.99
Best Naturals · Amazon.com · 🧠 Vitamin B6
CPS
Price
$6.99
Amazing Formulas · Amazon.com · 🧠 Vitamin B6
CPS
Price
$14.49
Amazon.com · 🧠 Vitamin B6
CPS
Price
$14.99
BulkSupplements.com · Amazon.com · 🧠 Vitamin B6
CPS
Price
$18.97
Amazon.com · 🧠 Vitamin B6
CPS
Price
$18.99
Bluebonnet · Amazon.com · 🧠 Vitamin B6
CPS
Price
$11.16
Best Naturals · Amazon.com · 🧠 Vitamin B6
CPS
Price
$17.98
Nature's Way · Amazon.com · 🧠 Vitamin B6
CPS
Price
$8.87
Amazon.com · 🧠 Vitamin B6
CPS
Price
$4.69
Vitamatic · Amazon.com · 🧠 Vitamin B6
CPS
Price
$9.99
Horbäach · Amazon.com · 🧠 Vitamin B6
CPS
Price
$8.74
Best Naturals · Amazon.com · 🧠 Vitamin B6
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$26.24
Amazon.com · 🅱️ B-Complex
CPS
Price
$24.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$23.99
Yes. Cycloserine (an antibiotic) increases urinary pyridoxine excretion. Antiepileptic drugs like valproic acid, carbamazepine, and phenytoin raise vitamin B6 catabolism, lowering plasma PLP; pyridoxine can reduce phenytoin and phenobarbital levels. Theophylline users often have low plasma PLP. Discuss your vitamin B6 status with your health care provider. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Horbäach B6 Vitamin 50mg | 250 Tablets | Non-GMO & Gluten Free Supplement at $0.03 per serving — the lowest cost-per-dose vitamin b6 in our catalog. See the full ranking on the Best Vitamin B6 page.
We're tracking 103 active Vitamin B6 deals across Amazon US and partner retailers, ranked by community votes and cost-per-dose — not paid placement.
Across 77 tracked Vitamin B6 deals the median cost-per-dose is $0.100; the cheapest quartile comes in under $0.058 per serving. Anything below the median is a solid deal for the same molecule.
Deals are submitted by the community and ranked by net votes (hot minus cold) plus cost-per-dose normalised across container sizes. We take no affiliate kickbacks for ordering; sponsored slots, when present, are clearly badged.
High intakes of vitamin B6 from food sources have not been reported to cause adverse effects, but chronic intake of 1–6 g of oral pyridoxine per day for 12–40 months can cause severe, progressive sensory neuropathy with ataxia; other effects include painful, disfiguring skin lesions, photosensitivity, and gastrointestinal symptoms such as nausea and heartburn. The Food and Nutrition Board set a Tolerable Upper Intake Level (UL) of 100 mg/day for adults, with lower ULs for children and adolescents — per the NIH Office of Dietary Supplements.
Vitamin B6 is found in a wide variety of foods, and its richest sources include fish, beef liver and other organ meats, potatoes and other starchy vegetables, and fruit (other than citrus). In the United States, adults obtain most of their dietary vitamin B6 from fortified cereals, beef, poultry, starchy vegetables, and some noncitrus fruits; about 75% of vitamin B6 from a mixed diet is bioavailable — per the NIH Office of Dietary Supplements.
Dosage, upper-limit, deficiency, food-source and interaction facts are sourced from the NIH Office of Dietary Supplements Vitamin B6 fact sheet. General information, not medical advice.
45 servings · ~45-day supply
240 servings · ~240-day supply
120 servings · ~120-day supply
500 servings · ~500-day supply
