Bluebonnet Nutrition Liquid Cellular Active Methycobalamin…
BluebonnetAmazon.com
$0.34/serving
$19.960°
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Vitamin B12 (Cobalamin)
vitamin · 197 active deals
How much does Vitamin B12 (Cobalamin) cost?
The best-value Vitamin B12 (Cobalamin) right now is about $0.02 per dose — across the 141 we can price per dose the median is $0.141/dose, so shopping on cost-per-dose can cut your cost several-fold. Every Vitamin B12 (Cobalamin) deal here is ranked by cost per dose — what you actually pay per serving, not the sticker price — because forms and absorption differ, so the cheapest bottle isn’t always the cheapest dose.
Prices checked · live from the Amazon US catalog.
Right now the best value across our full Vitamin B12 (Cobalamin) catalog is at $0.02 per serving.
Median $0.141/servingCheapest quartile under $0.069across 141 tracked Vitamin B12 (Cobalamin) deals
Recommended daily intake
Daily Value 2.4 mcgUpper limit none established
No established upper limit — excess is excreted. Supplements commonly use far more than the DV. General FDA/NIH adult guidance — not medical advice.
What Vitamin B12 (Cobalamin) does
Vitamin B12 is a water-soluble vitamin that the NIH says is required for the development, myelination, and function of the central nervous system, for healthy red blood cell formation, and for DNA synthesis. It works as a cofactor for two enzymes — methionine synthase, which converts homocysteine to the amino acid methionine, and L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate (a short-chain fatty acid). The fact sheet notes that researchers have looked at vitamin B12 in relation to cancer, cardiovascular disease, dementia and cognitive function, and energy and endurance, but it describes the evidence as mixed or inconclusive — for example, the evidence on vitamin B12 and cancer risk points in conflicting directions. More research is needed to clarify these associations — per the NIH Office of Dietary Supplements; not medical advice.
Forms & absorption
According to the NIH, methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12, while hydroxycobalamin and cyanocobalamin become biologically active only after the body converts them to those active forms. In dietary supplements the most common form is cyanocobalamin, with adenosylcobalamin, methylcobalamin, and hydroxycobalamin also used; the fact sheet states that no evidence indicates absorption rates differ by form, and that absorption is about 50% at doses below the intrinsic-factor binding capacity (less than 1–2 mcg) but substantially lower at higher doses (about 2% at 500 mcg). Vitamin B12 is also sold in sublingual tablets or lozenges, and the sheet notes evidence suggests no difference in efficacy between oral and sublingual forms.
Food sources of Vitamin B12 (Cobalamin)
Vitamin B12 is present naturally in foods of animal origin, including fish, meat, poultry, eggs, and dairy products. The richest sources listed are beef liver and clams; oysters and fortified nutritional yeasts are also very high. Plant foods do not naturally contain vitamin B12, but fortified breakfast cereals and fortified nutritional yeasts are readily available sources with high bioavailability — per the NIH Office of Dietary Supplements.
Vitamin B12 (Cobalamin) deficiency — who's at risk
Groups most likely to be deficient include older adults (especially those with atrophic gastritis), people with pernicious anemia, people with gastrointestinal disorders such as celiac or Crohn's disease, those who have had gastrointestinal surgery, people who follow vegetarian or vegan diets, and the breastfed infants of women who follow vegan diets. Effects can include megaloblastic anemia, fatigue, glossitis of the tongue, palpitations, low blood cell counts, and neurological changes such as numbness and tingling in the hands and feet, with early intervention important to avoid irreversible damage. Because the body stores about 1 to 5 mg of vitamin B12, symptoms can take several years to appear — per the NIH Office of Dietary Supplements.
When and how to take Vitamin B12 (Cobalamin)
Vitamin B12 is water-soluble and best taken in the morning, as it can be mildly energising for some people. It can be taken with or without food. Sublingual and oral forms both work; the methylcobalamin form is the active one.
Can you take Vitamin B12 (Cobalamin) with other supplements?
Long-term use of metformin or acid-reducing drugs (PPIs) can lower B12 levels, so people on those are more likely to need it. It stacks well in a B-complex.
General guidance on timing and absorption, not medical advice. Check with a clinician about your medications and conditions.
Natural Factors, Vitamin B12 Cyanocobalamin 1000 mcg, Supports…
Natural FactorsAmazon.com
$0.14/serving
$8.370°
Amazon Elements Vitamin B12 Methylcobalamin 5000 mcg - Normal…
Amazon ElementsAmazon.com
$0.17/serving
$11.150°
Amazing Formulas Vitamin B12 (Cyanocobalamin) 1000 Mcg per…
Amazing NutritionAmazon.com
$0.06/serving
$16.990°
Superior Source No Shot Vitamin B-12 Cyanocobalamin 1000 mcg
Superior SourceAmazon.com
$0.12/serving
$11.530°
Multivitamin for Men - B-Complex & B12 | Whole Foods & Enzymes…
NUTRAHARMONYAmazon.com
$0.24/serving
$21.890°
Igennus Sublingual Vitamin B12 Complex 1000mcg, 180 Tablets
Igennus Healthcare NutritionAmazon.com
$0.11/serving
$19.950°
Vitamin B Complex for Men & Women - Full B-Complex & Vitamin…
NUTRAHARMONYAmazon.com
$0.36/serving
$21.490°
ACV Apple Cider Vinegar Gummies - Natural Energy Supplement…
Natures CraftAmazon.com
$0.17/serving
$19.980°
Essential Elements Apple Cider Vinegar Gummies from The Mother…
Essential ElementsAmazon.com
$0.38/serving
$23.000°
Apple Cider Vinegar Gummies with Mother - Cleanse & Detox ACV…
Natures CraftAmazon.com
$0.17/serving
$9.990°
Apple Cider Vinegar Gummies Zero Sugar - Max Strength ACV…
Health Nutrition NaturalsAmazon.com
$0.11/serving
$12.820°
Methylcobalamine B12 1000mcg/1mg - SuperSmart | Sublingual…
SuperSmart USA LLCSuperSmart
$0.20/serving
$20.000°
Vykee Nutrition B Complex Supplement – High-Potency B Vitamins…
Vykee NutritionAmazon.com
$0.22/serving
$26.990°
BlueBonnet Stress Vitamin B Complex for Women & Men - Daily…
BluebonnetAmazon.com
$0.31/serving
$15.600°
Bariatric Fusion Vitamin B12 Sublingual 1000 mcg Melts…
Bariatric FusionAmazon.com
$0.18/serving
$16.340°
Vitamin B12 1000mcg Vegetarian Friendly Non-GMO, 250 Tablets
FuturebioticsAmazon.com
$0.04/serving
$9.990°
ARG B12 Adenosylcobalamin - 3000 mcg with Folate - Bioactive…
Allergy Research GroupAmazon.com
$0.39/serving
$23.490°
Seeking Health Adeno B12 - Vitamin B Supplement to Support…
Seeking HealthAmazon.com
$0.40/serving
$24.000°
Micro Ingredients Vitamin B12 1,000 mcg | Methylcobalamin…
Micro IngredientsAmazon.com
$0.05/serving
$19.990°
Vitamatic Vitamin B12 1000 mcg Fast Dissolve Tablets – Natural…
VitamaticAmazon.com
$0.05/serving
$18.990°
USDA Organic Vitamin B12 Sublingual Spray - 5000 mcg Liquid…
NUTRAHARMONYAmazon.com
$0.41/serving
$24.890°
COMPLEMENT Vegan Vitamin Triple B12 Liquid Spray- 1500 mcg B12…
ComplementAmazon.com
$0.33/serving
$19.500°
Nature's Bounty Vitamin B12, Supports Energy Metabolism…
Nature's BountyAmazon.com
$0.10/serving
$9.990°
Piping Rock Vitamin B12 | 500 mcg | 250 Tablets | Supplement…
Piping RockAmazon.com
$0.03/serving
$8.490°
Nature's Truth B12 Vitamin | 500 mcg | 120 Tablets | Vegan
Nature's TruthAmazon.com
$0.06/serving
$6.990°
NatureWise Vitamin B12 500 mcg - B12 Supplement for Energy +…
NatureWiseAmazon.com
$0.08/serving
$7.990°
Every Vitamin B12 (Cobalamin) deal above is ranked by real cost per dose with no paid placement — see our and .
Independent testing
3 of 44 tracked Vitamin B12 (Cobalamin) brands here are flagged as carrying independent third-party testing — a voluntary check of a product's identity, potency and contaminants by an outside lab. It's a quality signal, not a value or efficacy claim. Confirm any brand's current status on the official registries:
Testing status is self-reported by the brand or drawn from public certification and may change — always verify on the official registry before purchase.
Vitamin B12 (Cobalamin) — dosage, safety & deals FAQ
- How much Vitamin B12 do you need per day?
The for adults 19+ is 2.4 mcg daily; 2.6 mcg in pregnancy and 2.8 mcg during lactation. Adolescents 14-18 also need 2.4 mcg. Younger children need 0.9-1.8 mcg. Infants have an Adequate Intake of 0.4 mcg (0-6 months) and 0.5 mcg (7-12 months). — per the NIH Office of Dietary Supplements; general information, not medical advice.
- Can you take too much Vitamin B12?
The Food and Nutrition Board did not establish a (UL) for vitamin B12 because of its low potential for toxicity. Even at large doses, vitamin B12 is generally considered safe because the body does not store excess amounts. — per the NIH Office of Dietary Supplements; general information, not medical advice.
- What are the signs of Vitamin B12 deficiency?
Effects can include megaloblastic anemia; low counts of white and red blood cells or platelets; glossitis of the tongue; fatigue; palpitations; pale skin; dementia; weight loss; and infertility. Neurological changes such as numbness and tingling in the hands and feet can also occur. Symptoms can take several years to appear. — per the NIH Office of Dietary Supplements; general information, not medical advice.
- Who is most likely to need more Vitamin B12?
Groups most likely to be deficient include older adults; people with pernicious anemia; people with gastrointestinal disorders like celiac or Crohn's disease; people who have had gastrointestinal surgery; people who follow vegetarian or vegan diets; and infants of women who follow vegan diets. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Vitamin B12 (Cobalamin) guides
Related vitamins
References & sources
- Vitamin B12: Fact Sheet for Health Professionals — NIH Office of Dietary Supplements
- USP Verified product participants — U.S. Pharmacopeia
- NSF certified products — NSF
We link primary sources and paraphrase their findings — never copy their text, tables, or images. Cost-per-dose figures are our own first-party catalog data.