NEW
🅱️ B-Complex
Cost per serving
$0.17
vitamin · 260 active deals
The best-value Vitamin B12 right now is about $0.04 per dose — across 220 tracked products the median is $0.139/dose, so shopping on cost-per-dose can cut your cost several-fold. Every Vitamin B12 deal here is ranked by cost per dose— what you actually pay per serving, not the sticker price — because forms and absorption differ, so the cheapest bottle isn’t always the cheapest dose.
Right now the best value across our full Vitamin B12 catalog is at $0.04 per serving.
Recommended daily intake
No established upper limit — excess is excreted. Supplements commonly use far more than the DV. General FDA/NIH adult guidance — not medical advice.
Vitamin B12 is a water-soluble vitamin that the NIH says is required for the development, myelination, and function of the central nervous system, for healthy red blood cell formation, and for DNA synthesis. It works as a cofactor for two enzymes — methionine synthase, which converts homocysteine to the amino acid methionine, and L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate (a short-chain fatty acid). The fact sheet notes that researchers have looked at vitamin B12 in relation to cancer, cardiovascular disease, dementia and cognitive function, and energy and endurance, but it describes the evidence as mixed or inconclusive — for example, the evidence on vitamin B12 and cancer risk points in conflicting directions. More research is needed to clarify these associations — per the NIH Office of Dietary Supplements; not medical advice.
According to the NIH, methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12, while hydroxycobalamin and cyanocobalamin become biologically active only after the body converts them to those active forms. In dietary supplements the most common form is cyanocobalamin, with adenosylcobalamin, methylcobalamin, and hydroxycobalamin also used; the fact sheet states that no evidence indicates absorption rates differ by form, and that absorption is about 50% at doses below the intrinsic-factor binding capacity (less than 1–2 mcg) but substantially lower at higher doses (about 2% at 500 mcg). Vitamin B12 is also sold in sublingual tablets or lozenges, and the sheet notes evidence suggests no difference in efficacy between oral and sublingual forms.
Vitamin B12 is present naturally in foods of animal origin, including fish, meat, poultry, eggs, and dairy products. The richest sources listed are beef liver and clams; oysters and fortified nutritional yeasts are also very high. Plant foods do not naturally contain vitamin B12, but fortified breakfast cereals and fortified nutritional yeasts are readily available sources with high bioavailability — per the NIH Office of Dietary Supplements.
Groups most likely to be deficient include older adults (especially those with atrophic gastritis), people with pernicious anemia, people with gastrointestinal disorders such as celiac or Crohn's disease, those who have had gastrointestinal surgery, people who follow vegetarian or vegan diets, and the breastfed infants of women who follow vegan diets. Effects can include megaloblastic anemia, fatigue, glossitis of the tongue, palpitations, low blood cell counts, and neurological changes such as numbness and tingling in the hands and feet, with early intervention important to avoid irreversible damage. Because the body stores about 1 to 5 mg of vitamin B12, symptoms can take several years to appear — per the NIH Office of Dietary Supplements.
Every Vitamin B12 deal above is ranked by real cost per dose with no paid placement — see our and .
The for adults 19+ is 2.4 mcg daily; 2.6 mcg in pregnancy and 2.8 mcg during lactation. Adolescents 14-18 also need 2.4 mcg. Younger children need 0.9-1.8 mcg. Infants have an Adequate Intake of 0.4 mcg (0-6 months) and 0.5 mcg (7-12 months). — per the NIH Office of Dietary Supplements; general information, not medical advice.
The Food and Nutrition Board did not establish a (UL) for vitamin B12 because of its low potential for toxicity. Even at large doses, vitamin B12 is generally considered safe because the body does not store excess amounts. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Effects can include megaloblastic anemia; low counts of white and red blood cells or platelets; glossitis of the tongue; fatigue; palpitations; pale skin; dementia; weight loss; and infertility. Neurological changes such as numbness and tingling in the hands and feet can also occur. Symptoms can take several years to appear. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Groups most likely to be deficient include older adults; people with pernicious anemia; people with gastrointestinal disorders like celiac or Crohn's disease; people who have had gastrointestinal surgery; people who follow vegetarian or vegan diets; and infants of women who follow vegan diets. — per the NIH Office of Dietary Supplements; general information, not medical advice.
We link primary sources and paraphrase their findings — never copy their text, tables, or images. Cost-per-dose figures are our own first-party catalog data.
Cost per serving
$0.17
Cost per serving
$0.70
30 servings · ~30-day supply
Cost per serving
$0.08
480 servings · ~480-day supply
Cost per serving
$0.25
120 servings · ~120-day supply
Cost per serving
$0.17
120 servings · ~120-day supply
Cost per serving
$0.03
300 servings · ~300-day supply
Cost per serving
$0.17
60 servings · ~60-day supply
Cost per serving
$0.31
50 servings · ~50-day supply
Cost per serving
$0.25
120 servings · ~120-day supply
Cost per serving
$0.28
100 servings · ~100-day supply
Cost per serving
$0.06
180 servings · ~180-day supply
Cost per serving
$0.50
60 servings · ~60-day supply
Cost per serving
$0.14
70 servings · ~70-day supply
Cost per serving
$0.16
60 servings · ~60-day supply
Cost per serving
$0.26
90 servings · ~90-day supply
Cost per serving
$0.40
60 servings · ~60-day supply
Cost per serving
$0.30
Pricey60 servings · ~60-day supply
Cost per serving
$0.17
Avg·−42%Cost per serving
$0.32
120 servings · ~120-day supply
Cost per serving
$0.10
240 servings · ~240-day supply
Cost per serving
$0.60
30 servings · ~30-day supply
Cost per serving
$0.19
90 servings · ~90-day supply
Cost per serving
$0.21
90 servings · ~90-day supply
Cost per serving
$0.07
Cheap·−79%100 servings · ~100-day supply
Cost per serving
$0.22
Avg200 servings · ~200-day supply
Cost per serving
$0.60
60 servings · ~60-day supply
Cost per serving
$0.25
60 servings · ~60-day supply
Cost per serving
$0.05
Cheap·−84%250 servings · ~250-day supply
Cost per serving
$0.04
Cheap·−88%250 servings · ~250-day supply
Cost per serving
$0.30
60 servings · ~60-day supply
Cost per serving
$0.08
200 servings · ~200-day supply
Cost per serving
$0.19
120 servings · ~120-day supply
Cost per serving
$0.07
250 servings · ~250-day supply
Cost per serving
$0.10
Avg·−68%100 servings · ~100-day supply
Cost per serving
$0.15
100 servings · ~100-day supply
Cost per serving
$0.06
Cheap·−82%100 servings · ~100-day supply
Cost per serving
$0.16
Avg·−43%60 servings · ~60-day supply
Cost per serving
$0.19
90 servings · ~90-day supply
Cost per serving
$0.04
Cheap·−88%250 servings · ~250-day supply
Cost per serving
$0.14
180 servings · ~180-day supply
Cost per serving
$0.22
Avg90 servings · ~90-day supply
Cost per serving
$0.39
Pricey60 servings · ~60-day supply
Cost per serving
$0.40
Pricey60 servings · ~60-day supply
Cost per serving
$0.26
60 servings · ~60-day supply
Cost per serving
$0.17
Avg·−40%90 servings · ~90-day supply
Cost per serving
$0.40
Pricey60 servings · ~60-day supply
Cost per serving
$0.33
60 servings · ~60-day supply
Cost per serving
$0.50
60 servings · ~60-day supply
Cost per serving
$0.05
365 servings · ~365-day supply
Cost per serving
$0.05
Cheap·−86%365 servings · ~365-day supply
Cost per serving
$0.04
Cheap·−88%250 servings · ~250-day supply
Cost per serving
$0.07
150 servings · ~150-day supply
Cost per serving
$0.44
45 servings · ~45-day supply
Cost per serving
$0.36
60 servings · ~60-day supply
Cost per serving
$0.33
60 servings · ~60-day supply
Cost per serving
$0.09
100 servings · ~100-day supply
Cost per serving
$0.16
Avg·−45%100 servings · ~100-day supply
Cost per serving
$0.06
Cheap·−81%300 servings · ~300-day supply
Cost per serving
$0.04
250 servings · ~250-day supply
Cost per serving
$0.06
Cheap·−82%120 servings · ~120-day supply
Cost per serving
$0.13
Avg·−54%100 servings · ~100-day supply
Cost per serving
$0.06
240 servings · ~240-day supply
Cost per serving
$0.08
Cheap·−76%100 servings · ~100-day supply
Cost per serving
$0.05
250 servings · ~250-day supply
Cost per serving
$0.06
Cheap·−83%300 servings · ~300-day supply
Cost per serving
$0.11
Avg·−64%100 servings · ~100-day supply
Cost per serving
$0.03
Cheap·−90%300 servings · ~300-day supply
Cost per serving
$0.19
Avg·−35%120 servings · ~120-day supply
Cost per serving
$0.11
90 servings · ~90-day supply
Cost per serving
$0.41
90 servings · ~90-day supply
Cost per serving
$0.16
Avg·−44%120 servings · ~120-day supply
Cost per serving
$0.11
Avg·−65%Amazon.com · 🅱️ B-Complex
CPS
Price
$19.89
Amazon.com · 🅱️ B-Complex
CPS
Price
$20.98
Amazon.com · 🅱️ B-Complex
CPS
Price
$39.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$29.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$19.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$15.60
Amazon.com · 🅱️ B-Complex
CPS
Price
$29.59
Amazon.com · 🅱️ B-Complex
CPS
Price
$27.60
Amazon.com · 🅱️ B-Complex
CPS
Price
$9.99
Amazon.com · 🅱️ B-Complex
CPS
Price
$29.95
Amazon.com · 🅱️ B-Complex
CPS
Price
$10.12
Amazon.com · 💉 Methylcobalamin
CPS
Price
$9.49
Amazon.com · 💉 Methylcobalamin
CPS
Price
$22.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$23.95
Amazon.com · ⚡ Vitamin B12
CPS
Price
$17.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$19.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$37.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$22.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$17.95
Amazon.com · ✨ Collagen Peptides
CPS
Price
$16.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$18.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$6.94
Amazon.com · ⚡ Vitamin B12
CPS
Price
$44.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$35.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$14.97
Amazon.com · ⚡ Vitamin B12
CPS
Price
$13.46
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$17.80
Amazon.com · 💉 Methylcobalamin
CPS
Price
$15.70
Amazon.com · 💉 Methylcobalamin
CPS
Price
$23.00
Amazon.com · 💉 Methylcobalamin
CPS
Price
$16.87
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.81
Amazon.com · 💉 Methylcobalamin
CPS
Price
$15.18
Amazon.com · ⚡ Vitamin B12
CPS
Price
$5.79
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.78
Amazon.com · 💉 Methylcobalamin
CPS
Price
$16.65
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$25.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$19.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$23.49
Amazon.com · ⚡ Vitamin B12
CPS
Price
$24.00
Amazon.com · 💉 Methylcobalamin
CPS
Price
$15.59
Amazon.com · ⚡ Vitamin B12
CPS
Price
$15.59
Amazon.com · ⚡ Vitamin B12
CPS
Price
$24.00
Amazon.com · 💉 Methylcobalamin
CPS
Price
$20.00
Amazon.com · 💉 Methylcobalamin
CPS
Price
$30.00
Amazon.com · 💉 Methylcobalamin
CPS
Price
$19.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$17.09
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$9.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$19.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$21.89
Amazon.com · 🅱️ B-Complex
CPS
Price
$19.50
Amazon.com · 💉 Methylcobalamin
CPS
Price
$9.16
Amazon.com · ⚡ Vitamin B12
CPS
Price
$15.60
Amazon.com · ⚡ Vitamin B12
CPS
Price
$18.75
Amazon.com · 💉 Cyanocobalamin
CPS
Price
$8.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$7.09
Amazon.com · ⚡ Vitamin B12
CPS
Price
$12.95
Amazon.com · 💉 Methylcobalamin
CPS
Price
$13.95
Amazon.com · ⚡ Vitamin B12
CPS
Price
$7.99
Amazon.com · 💉 Cyanocobalamin
CPS
Price
$12.79
Amazon.com · ⚡ Vitamin B12
CPS
Price
$16.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$10.69
Amazon.com · ⚡ Vitamin B12
CPS
Price
$9.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$22.89
Amazon.com · 💉 Methylcobalamin
CPS
Price
$9.99
Amazon.com · 💉 Methylcobalamin
CPS
Price
$36.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$18.99
Amazon.com · ⚡ Vitamin B12
CPS
Price
$18.99
Yes. Gastric acid inhibitors (proton pump inhibitors like omeprazole and lansoprazole, and H2 antagonists like cimetidine and ranitidine) can interfere with vitamin B12 absorption from food and lead to deficiency. Metformin might reduce vitamin B12 absorption and significantly lower serum concentrations. — per the NIH Office of Dietary Supplements; general information, not medical advice.
Piping Rock Vitamin B12 | 500 mcg | 250 Tablets | Supplement for Women and Men… at $0.04 per serving — the lowest cost-per-dose vitamin b12 in our catalog. See the full ranking on the Best Vitamin B12 page.
We're tracking 260 active Vitamin B12 deals across Amazon US and partner retailers, ranked by community votes and cost-per-dose — not paid placement.
Across 220 tracked Vitamin B12 deals the median cost-per-dose is $0.139; the cheapest quartile comes in under $0.082 per serving. Anything below the median is a solid deal for the same molecule.
Deals are submitted by the community and ranked by net votes (hot minus cold) plus cost-per-dose normalised across container sizes. We take no affiliate kickbacks for ordering; sponsored slots, when present, are clearly badged.
Vitamin B12 is present naturally in foods of animal origin, including fish, meat, poultry, eggs, and dairy products. The richest sources listed are beef liver and clams; oysters and fortified nutritional yeasts are also very high. Plant foods do not naturally contain vitamin B12, but fortified breakfast cereals and fortified nutritional yeasts are readily available sources with high bioavailability — per the NIH Office of Dietary Supplements.
Dosage, upper-limit, deficiency, food-source and interaction facts are sourced from the NIH Office of Dietary Supplements Vitamin B12 fact sheet. General information, not medical advice.
120 servings · ~120-day supply
120 servings · ~120-day supply
180 servings · ~180-day supply
